Gastrointestinal Transit and Drug Absorption

Slows Gastrointestinal Transit in Rats

R.J. KOSLO, J.L. VAUGHT, A. COWAN, D.E. G M E R E K and F. PORRECA, lntrathecal morphine slows gastrointestinal transit in rats, European J. Pharmacol. 119 (1985) 243-246. Intrathecal (i.th.) (by direct lumbar puncture) and intraperitoneal (i.p.) administration of morphine (30-100/~g/rat) caused a dose-related inhibition of gastrointestinal transit in the rat. Pretreatment with i.th. naloxone (...

Effects of gravity on gastric emptying, intestinal transit, and drug absorption.

The effects of microgravity on the physiologic response of the human body, the physical properties of gastrointestinal contents, and the influence these responses have on drug absorption are becoming more and more critical as the duration of humans in the hostile space environment dramatically increases. In this environment, some conventional oral dosage forms may be severely limited as an effe...

Effects of Artemisia dracunculus essential oil on diarrhea and intestinal transit time in rat gastrointestinal tract

Introduction: Artemisia dracunculus L. belongs to Asteraceae family, and is a medicinal plant widely used in traditional medicine as a remedy for gastrointestinal disturbances. This study was undertaken to evaluate the effects of essential oil of A. dracunculus (EOAD) on the rat alimentary tract. Methods: The EOAD was extracted by Clevenger apparatus using hydrodistillation. LD50 was calcula...

MORPHINE AND APOMORPHINE INHIBIT GASTROINTESTINAL TRANSIT (GIT) THROUGH TWO DIFFERENT MECHANISMS

Morphine was used as a remedy for the control of diarrhea centuries before it's sedative-analgesic effect was discovered. Although several mechanisms have been proposed for the morphine-induced inhibition of gastrointestinal transit (OIT), the exact mechanism has not yet been identified. On this basis the possible involvement of the dopaminergic system in morphine-induced inhibition of tra...

Measurement of gastrointestinal transit using radioactive chromium.